1045520

Azacitidine

United States Pharmacopeia (USP) Reference Standard

• Sinônimo(s): 5-Azacytidine, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, Ladakamycin
• Fórmula empírica (Notação de Hill): C₈H₁₂N₄O₅
• Número CAS: 320-67-2
• Peso molecular: 244.20
• Beilstein: 620461
• Número MDL: MFCD00006539
• Código UNSPSC: 41116107
• ID de substância PubChem: 329749084
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: azacitidine
• fabricante/nome comercial: USP
• pf: 226-232 °C (dec.) (lit.)
• aplicação(ões): pharmaceutical (small molecule)
• formato: neat
• cadeia de caracteres SMILES: NC1=NC(=O)N(C=N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
• InChI: 1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
• chave InChI: NMUSYJAQQFHJEW-KVTDHHQDSA-N
• Informações sobre genes: human ... DNMT1(1786) , DNMT3A(1788)

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Azacitidine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Ações bioquímicas/fisiológicas

A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS07,GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H302 - H341 - H350 - H360FD - H372 - H410
• Declarações de precaução: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 1A - Muta. 2 - Repr. 1B - STOT RE 1
• Código de classe de armazenamento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3