X1875
Xanthine Oxidase from bovine milk
Grade I, ammonium sulfate suspension, ≥0.4 units/mg protein
Sinônimo(s):
XOD, Xanthine:oxygen oxidoreductase
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About This Item
Número CAS:
Número da licença da enzima:
1.17.3.2.
Número CE:
Número MDL:
Código UNSPSC:
12352204
NACRES:
NA.54
Produtos recomendados
tipo
Grade I
Nível de qualidade
Formulário
ammonium sulfate suspension
atividade específica
≥0.4 units/mg protein
atividade externa
uricase ≤0.5%
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
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Descrição geral
Formerly E.C. 1.1.3.22
Xanthine Oxidase (XOD) is a metal flavoprotein. It has flavin adenine dinucleotide (FAD), molybdenum and iron in the ratio 2:2:8. This homodimer has a molecule weight of 290kDa. It is a member of the molybdenum-protein family. This enzyme consists of two separated substrate-binding sites.
Aplicação
Xanthine Oxidase from bovine milk has been used:
- in the preparation of xanthine oxidase (XO) solution for 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO)-spin trapping assay
- in in vitro XO assay for screening Vietnamese medicinal plants for XO inhibitory activity
- as a standard to determine XO activity
- as a standard to test the synergistic effect of docosahexaenoic acid (DHA)
Ações bioquímicas/fisiológicas
Hydroxylation of hypoxanthine to xanthine and xanthine to uric acid is catalyzed by xanthinebb oxidase (XO) enzyme.
Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.
Xanthine oxidase was shown to be involved in the reduction of cytochrome c by the generation of superoxide anions following the oxidation of xanthine. These free radicals are responsible for reducing cytochrome c.
Definição da unidade
One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.
forma física
Suspension in 2.3 M (NH4)2SO4 containing 1 mM sodium salicylate
Nota de análise
Protein determined by biuret
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Resp. Sens. 1
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Artigos
Instructions for working with enzymes supplied as ammonium sulfate suspensions
Protocolos
Enzymatic Assay of Superoxide Dismutase
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