WH0004149M1
Monoclonal Anti-MAX antibody produced in mouse
clone 4E10-1A9, purified immunoglobulin, buffered aqueous solution
Sinônimo(s):
Anti-MGC10775, Anti-MGC11225, Anti-MGC18164, Anti-MGC34679, Anti-MGC36767, Anti-MYC associated factor X, Anti-orf1
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About This Item
Produtos recomendados
fonte biológica
mouse
conjugado
unconjugated
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
4E10-1A9, monoclonal
forma
buffered aqueous solution
reatividade de espécies
human
técnica(s)
immunofluorescence: suitable
indirect ELISA: suitable
proximity ligation assay: suitable
western blot: 1-5 μg/mL
Isotipo
IgG2aκ
nº de adesão GenBank
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... MAX(4149)
Categorias relacionadas
Descrição geral
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown. (provided by RefSeq)
Imunogênio
MAX (AAH03525, 1 a.a. ~ 151 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
Sequence
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
Ações bioquímicas/fisiológicas
Myc-associated factor X (MAX) interacts with N-, L-, and c-Myc proteins both in vitro and in vivo. MAX plays a vital role in the regulation of the MYC/MAX/ MAX dimerization protein (MXD) network of basic helix-loop-helix leucine zipper (bHLHZip) transcription factors implicated in cell proliferation, differentiation, and apoptosis. Mutation of the gene leads to pheochromocytomas and paragangliomas (PPGLs). Heterodimer complex of c-Myc and Max proteins stimulates the transcription at target promoters by binding hexameric DNA consensus sequences “CANNTG” (E-boxes). Apart from this, Max hinders MYC-dependent cell transformation by transcriptional repression of the same E-boxes by associating with various repressors such as MXD, MAX network transcriptional repressor (MNT), and MAX gene-associated protein (MGA). Gene transcription activated by MYC–MAX heterodimers can be repressed by Max homodimers by decreasing the level of free MAX monomers and by binding to E-box DNA sequences.
forma física
Solution in phosphate buffered saline, pH 7.4
Informações legais
GenBank is a registered trademark of United States Department of Health and Human Services
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Nan Qin et al.
International journal of cancer, 135(9), 2054-2064 (2014-03-29)
Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To explore whether phenotypic differences among PPGLs reflect a MAX-mediated mechanism and opposing influences of hypoxia-inducible factor
A D Gilladoga et al.
Oncogene, 7(6), 1249-1251 (1992-06-01)
The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and
Iñaki Comino-Méndez et al.
Nature genetics, 43(7), 663-667 (2011-06-21)
Hereditary pheochromocytoma (PCC) is often caused by germline mutations in one of nine susceptibility genes described to date, but there are familial cases without mutations in these known genes. We sequenced the exomes of three unrelated individuals with hereditary PCC
Iñaki Comino-Méndez et al.
Journal of molecular medicine (Berlin, Germany), 93(11), 1247-1255 (2015-06-14)
The presence of germline mutations affecting the MYC-associated protein X (MAX) gene has recently been identified as one of the now 11 major genetic predisposition factors for the development of hereditary pheochromocytoma and/or paraganglioma. Little is known regarding how missense
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