W102

(R)-(+)-WIN 55,212-2 mesylate salt

≥98% (HPLC), powder, CB2 agonist

• Sinônimo(s): (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt, WIN 55212-2 methanesulfonate, WIN 552122 mesylate
• Fórmula linear: C₂₇H₂₆N₂O₃ · CH₃SO₃H
• Número CAS: 131543-23-2
• Peso molecular: 522.61
• Número MDL: MFCD00153882
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278779
• NACRES: NA.77

Propriedades

• Nome do produto: (R)-(+)-WIN 55,212-2 mesylate salt, ≥98% (HPLC)
• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• controle de medicamentos: regulated under CDSA - not available from Sigma-Aldrich Canada
• cor: white to beige
• solubilidade: 0.1 M HCl: 0.25 mg/mL; DMSO: 12 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.4 mg/mL; 0.1 M NaOH: insoluble; H₂O: insoluble
• cadeia de caracteres SMILES: CS(O)(=O)=O.Cc1c(C(=O)c2cccc3ccccc23)c4cccc5OC[C@@H](CN6CCOCC6)n1c45
• InChI: 1S/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28;1-5(2,3)4/h2-11,20H,12-17H2,1H3;1H3,(H,2,3,4)/t20-;/m1./s1
• chave InChI: FSGCSTPOPBJYSX-VEIFNGETSA-N
• Informações sobre genes: human ... CNR1(1268) , CNR2(1269)

Descrição

Descrição geral

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

Aplicação

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/− mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

Ações bioquímicas/fisiológicas

It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.

Características e benefícios

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

The solubility of this chemical in DMF has not been determined. However, various sources state this chemical can be solubilized in about 30 mg/ml of DMF.

Informações legais

Sold with the permission of Sterling-Winthrop, Inc.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)