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T3202

Sigma-Aldrich

Torsemide

≥98% (HPLC), solid

Sinônimo(s):

Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

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About This Item

Fórmula empírica (Notação de Hill):
C16H20N4O3S
Número CAS:
56211-40-6
Peso molecular:
348.42
Número MDL:
MFCD00866166
Código UNSPSC:
12352200
ID de substância PubChem:
329826741
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

solubilidade

DMSO: soluble 18 mg/mL
H2O: insoluble

originador

Roche

cadeia de caracteres SMILES

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

chave InChI

NGBFQHCMQULJNZ-UHFFFAOYSA-N

Informações sobre genes

human ... SLC12A1(6557)

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Aplicação

Torsemide has been used as an inhibitor of Na+ Cl- co-transporter in transgenic Arabidopsis thaliana plants1.

Ações bioquímicas/fisiológicas

Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure2.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

Características e benefícios

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota de preparo

Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Warning

Frases de perigo

H319,H361fd

Classificações de perigo

Eye Irrit. 2 - Repr. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Livia Saleh et al.
Plant signaling & behavior, 8(6), e24259-e24259 (2013-04-23)
The involvement of chloride in salt stress symptoms and salt tolerance mechanisms in plants has been less investigated in the past. Therefore, we studied the salt-induced chloride influx in Arabidopsis expressing the GFP-based anion indicator Clomeleon. High salt concentrations induce
H A Friedel et al.
Drugs, 41(1), 81-103 (1991-01-01)
Torasemide (torsemide) is a high-ceiling loop diuretic which acts on the thick ascending limb of the loop of Henle to promote rapid and marked excretion of water, sodium and chloride. Like furosemide (frusemide), its major site of action is from
D V Preobrazhenskiĭ et al.
Kardiologiia, 51(4), 67-73 (2011-06-01)
Torasemide is a loop diuretic and has been used for the treatment of both acute and chronic congestive heart failure (CHF) and arterial hypertension (AH). Torasemide is similar to other loop diuretics in terms of its mechanism of diuretic action.
Loop diuretic therapy in left ventricular systolic dysfunction: has familiarity bred contempt for a critical but potentially nephrotoxic cardio renal therapy?
Robert J MacFadyen et al.
European journal of heart failure, 12(7), 649-652 (2010-06-26)
M J Barbanoj et al.
Clinical and experimental pharmacology & physiology, 36(5-6), 469-477 (2009-08-14)
1. The main objective of the present study was to compare the bioavailability/bioequivalence of a new prolonged-release (PR) formulation of torasemide with an immediate-release (IR) formulation. In addition, we assessed the pharmacokinetics of both formulations, as well as the urine
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