T123

Thioperamide maleate salt

solid

• Sinônimo(s): MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
• Fórmula empírica (Notação de Hill): C₁₅H₂₄N₄S · C₄H₄O₄
• Número CAS: 148440-81-7
• Peso molecular: 408.52
• Número MDL: MFCD00083209
• Código UNSPSC: 12352200
• ID de substância PubChem: 24277809
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: solid
• condição de armazenamento: desiccated; under inert gas
• cor: white
• solubilidade: H₂O: >10 mg/mL; DMSO: 12 mg/mL; ethanol: 3 mg/mL
• cadeia de caracteres SMILES: OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3
• InChI: 1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
• chave InChI: REZRBLGMJZZSID-BTJKTKAUSA-N
• Informações sobre genes: human ... HRH3(11255)

Descrição

Aplicação

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Ações bioquímicas/fisiológicas

Potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier.

Thioperamide is a potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

Características e benefícios

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves