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Documentos Principais

SRP6371

Sigma-Aldrich

Aldose Reductase human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sinônimo(s):

ADR, AKR1B1, ALDR1, ALR2, AR, Aldo-keto reductase family1, member B1

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About This Item

Código UNSPSC:
12352204
NACRES:
NA.32

fonte biológica

human

recombinante

expressed in E. coli

Ensaio

≥95% (SDS-PAGE)

Formulário

liquid

peso molecular

35.8 kDa (316 aa, 1-316 aa)

embalagem

pkg of 100 μg

concentração

1 mg/mL

nº de adesão UniProt

P15121

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... AKR1B1(231)

Descrição geral

Aldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) superfamily. Recombinant aldose reductase (AKR1B) protein was expressed in Escherichia coli and purified by using conventional chromatography techniques. It is expressed in eye and kidney, but predominant in placenta. The AKR1B1 gene is mapped to human chromosome 7q33.

Ações bioquímicas/fisiológicas

Aldose reductase (AKR1B1) catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. This protein is implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. AKR1B1 is also involved in cytokine-mediated generation of prostaglandin F2α (PGF2α) in preadipocytes. It participates in diabetes-associated mitochondrial disorder and damage via the activation of p53. AKR1B1 is associated with drug resistance mechanism in cancer-derived cell lines. It is also known to mediate cellular processes linked to carcinogenesis such as EMT (epithelial–mesenchymal transition), inflammation and angiogenesis. Aldose reductase mediates glucose metabolism in placenta and osmotic control in eye and kidney.

forma física

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H319

Classificações de perigo

Eye Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
8E06L73610
7F16L73610
6A10L73610
7C03L73610
3L02L73610

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Visite a Biblioteca de Documentos

Is rs759853 polymorphism in promoter of aldose reductase gene a risk factor for diabetic nephropathy? A meta-analysis.
Cui W, et al.
European Journal of Medical Research, 20, 14-14 (2015)
The human aldose reductase AKR1B1 qualifies as the primary prostaglandin F synthase in the endometrium.
Bresson E, et al.
The Journal of Clinical Endocrinology and Metabolism, 96, 210-219 (2011)
Prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue: modulation by inflammatory cytokines and role of the human aldose reductase AKR1B1.
Michaud A, et al.
PLoS ONE, 9, e90861-e90861 (2014)
Candidate locus analysis for PHACE syndrome.
Mitchell S, et al.
American Journal of Medical Genetics. Part A, 158(6), 1363-1367 (2012)
Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets.
Tang WH, et al.
Circulation, 129, 1598-1609 (2014)
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