SRP6125

Glyoxalase I human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Sinônimo(s): Aldoketomutase, GLO-1 methylglyoxalase, Glx 1, Lactoylglutathione lyase
• Código UNSPSC: 12352204
• NACRES: NA.32

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥90% (SDS-PAGE)
• forma: liquid
• peso molecular: 20.7 kDa (184 aa, 1-184 aa)
• embalagem: pkg of 100 μg
• nº de adesão NCBI: Q04760
• nº de adesão UniProt: Q04760
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... GLO1(2739)

Descrição

Descrição geral

GLO1 is involved in the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutathione. GLO1 is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. GLO1 enzyme is abundantly expressed and present in numerous tumor cell lines, in which its concentration is often upregulated ubiquitously. GLO1 is a major susceptible gene for autism in an ethnic Chinese population from Taiwan. GLO1 might be involved in the pathophysiology of mood disorders. GLO1 plays a role in the pathophysiology of mood disorders. Overexpression of GLO1 is associated with kidney tumor.

forma física

1 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.

Nota de preparo

Centrifuge the vial prior to opening.

Outras notas

MAEPQPPSGG LTDEAALSCC SDADPSTKDF LLQQTMLRVK DPKKSLDFYT RVLGMTLIQK CDFPIMKFSL YFLAYEDKND IPKEKDEKIA WALSRKATLE LTHNWGTEDD ETQSYHNGNS DPRGFGHIGI AVPDVYSACK RFEELGVKFV KKPDDGKMKG LAFIQDPDGY WIEILNPNKM ATLM

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H319
• Declarações de precaução: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classificações de perigo: Eye Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable