SRP5079
PTPRC (592-end), active, GST tagged from mouse
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinônimo(s):
B220, CD45R, Cd45, Ly-5, Lyt-4, T200, loc
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
recombinante
expressed in E. coli
Ensaio
≥70% (SDS-PAGE)
forma
buffered aqueous glycerol solution
atividade específica
8,415-11,385 nmol/min·mg
peso molecular
~116 kDa
nº de adesão NCBI
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
mouse ... Ptprc(19264)
Descrição geral
Protein tyrosine phosphatase, receptor type, C (PTPRC) or CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells.
Ações bioquímicas/fisiológicas
Protein tyrosine phosphatase, receptor type, C (PTPRC) has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling.
forma física
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota de preparo
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Mutation in the CD45 Inhibitory Wedge Modulates Integrin Activation and Leukocyte Recruitment during Inflammation
Giulia Germena
Journal of Immunology (2015)
High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
Gunnar Cario
Haematologica (2014)
E H Fischer et al.
Science (New York, N.Y.), 253(5018), 401-406 (1991-07-26)
Protein tyrosine phosphatases (PTPs) represent a diverse family of enzymes that exist as integral membrane and nonreceptor forms. The PTPs, with specific activities in vitro 10 to 1000 times greater than those of the protein tyrosine kinases would be expected
S J Ralph et al.
The EMBO journal, 6(5), 1251-1257 (1987-05-01)
Structural variation in the primary structure of human T200 glycoprotein has been detected. Three cDNA variants have been characterized each of which encode T200 molecules that differ in size as a result of sequence differences in their amino-terminal regions. The
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