SRP4739

PLGF-1 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

• Sinônimo(s): PGF, PIGF, PLGF 1, Placenta Growth Factor-1
• Número MDL: MFCD03458012
• Código UNSPSC: 12352202
• NACRES: NA.32

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥95% (HPLC); ≥95% (SDS-PAGE)
• Formulário: lyophilized
• peso molecular: ~29.7 kDa
• embalagem: pkg of 25 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• Impurezas: endotoxin, tested
• nº de adesão NCBI: AAD30179
• nº de adesão UniProt: P49763
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... PGF(5228)

Descrição

Descrição geral

PLGF (placental growth factor), originally identified in human placenta, is a member of the VEGF (vascular endothelial growth factor) family. This protein is predominantly expressed in placenta, and also shows expression in heart, thyroid, lung and skeletal muscle. It is alternatively spliced to produce three isoforms in humans namely, PLGF1, PLGF2 and PLGF3.
Recombinant mouse PLGF is a disulfide-linked homodimer containing two 142 amino acid polypeptide chains.

Ações bioquímicas/fisiológicas

PLGF (placental growth factor) is involved in angiogenesis, but does not play an essential role in angiogenesis during reproduction and development. However, inactivation of this gene in pathological conditions such as, ischemia, inflammation and cancer, results in impaired angiogenesis. Preclinical studies show that this protein might be a therapeutic target for treatment of angiogenesis and inflammation related disorders. In acute coronary syndrome (ACS) patients, increased levels of PLGF are linked with obstructive sleep apnea (OSA) and short-term adverse outcomes.

forma física

Sterile filtered and lyophilized with no additives.

Reconstituição

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute the protein in sterile 20 mM acetic acid to a concentration of 0.1-1.0 ug/ul. The solution can then be diluted into other aqueous buffer.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable