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Key Documents

SRP3231

Sigma-Aldrich

PF-4 from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sinônimo(s):

CXCL4, Ironplact, Oncostatin A, Platelet Factor-4

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

fonte biológica

mouse

recombinante

expressed in E. coli

Ensaio

≥98% (HPLC)
≥98% (SDS-PAGE)

forma

lyophilized

potência

10.0-100.0 ng/mL

peso molecular

8.2 kDa

embalagem

pkg of 1 mg
pkg of 20 μg

técnica(s)

cell culture | mammalian: suitable

Impurezas

<0.1 EU/μg endotoxin, tested

cor

white

nº de adesão UniProt

Q9Z126

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... PF4(56744)

Categorias relacionadas

Descrição geral

PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the a-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant murine PF-4 is an 8.2 kDa protein containing 76 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Ações bioquímicas/fisiológicas

PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the a-granules of platelets. Recombinant murine PF-4 is an 8.2 kDa protein containing 76 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Sequência

VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES

forma física

Lyophilized with no additives.

Reconstituição

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Kalyan Srivastava et al.
PloS one, 5(5), e10413-e10413 (2010-05-11)
Cerebral malaria continues to be a difficult to treat complication of Plasmodium falciparum infection in children. We have shown that platelets can have major deleterious immune functions in experimental cerebral malaria (ECM). One of the platelet derived mediators we have
S S Huang et al.
The Journal of biological chemistry, 257(19), 11546-11550 (1982-10-10)
A large scale purification procedure for the human platelet factor 4 proteoglycan carrier molecule has been developed. A yield of 46% and a 33,000-fold purification have been achieved, using poly-L-lysine-Sepharose affinity column chromatography, PF4-agarose affinity column chromatography, and Bio-Gel A-0.5m
B Scheuerer et al.
Blood, 95(4), 1158-1166 (2000-02-09)
Unstimulated monocytes rapidly undergo physiological changes resulting in programmed cell death (apoptosis) while stimuli promoting differentiation of these cells into macrophages were shown to inhibit apoptotic processes. In the present study, we report that the platelet-derived alpha-chemokine platelet factor 4

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