SRP0690

LKB1(STK11) Protein

recombinant

• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• recombinante: expressed in baculovirus infected Sf9 cells
• Ensaio: 70-95% (SDS-PAGE)
• forma: frozen liquid
• peso molecular: ~85 kDa
• concentração: 0.2 μg/μL
• nº de adesão: NM_000455
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... LKB1(6794)

Descrição

Aplicação

Useful for Western blot and in kinases assays as a downstream substrate for SRC or MEK1 kinases.

Ações bioquímicas/fisiológicas

Recombinant full-length human LKB1(STK11) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. LKB1(STK11) is a member of the serine/threonine kinase family which regulates cell polarity and functions as a tumor suppressor. STK11 is a critical barrier to pulmonary tumorigenesis which controlling initiation, differentiation, and metastasis. STK11 plays a central role in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in hematopoietic cells through a novel metabolic checkpoint ⁽¹⁾. STK11 serves as an essential regulator of HSCs and hematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem cell homeostasis ⁽²⁾.

Reconstituição

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

Armazenamento e estabilidade

Store in aliquots at -70°C. Avoid freeze/thaw cycles.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable