SML4014

Edrophonium chloride

≥98% (HPLC)

• Sinônimo(s): Dimethylethyl(3-hydroxyphenyl)ammonium chloride, Edrophone chloride, Ethyl(m-hydroxyphenyl)dimethylammonium chloride, N-Ethyl-3-hydroxy-N,N-dimethyl-benzenaminium chloride
• Fórmula empírica (Notação de Hill): C₁₀H₁₆NO·Cl
• Número CAS: 116-38-1
• Peso molecular: 201.69
• Número MDL: MFCD00055064
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: , Faint brown to very dark red brown
• solubilidade: DMSO: 2 mg/mL, clear (Warmed)
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: OC1=CC=CC([N+](CC)(C)C)=C1.[Cl-]
• InChI: 1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
• chave InChI: BXKDSDJJOVIHMX-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Bioavailable, acetylcholinesterase inhibitor with rapid onset and short duration of action.



Edrophonium chloride is a fast-acting, reversible and competitive inhibitor of acetylcholinesterase (AChE; Ki = 0.2, 0.2, and 0.4 μM in human red blood cells, purified calf forebrain, and octopus brain, respectively) with no effect on butyrylcholinesterase (BChE) activity. Edrophonium dispensing increases acetylcholine (ACh) levels in the neuromuscular junction to result in brief improvements in skeletal and muscular strength. Allosterically interacts with AChE-Serine103 and has a rapid onset of action occurring within 1 minute of administration and a short duration of action lasting 10 minutes with a very short half-life of 2–5 min (intravenous). Atropine, a competitive inhibitor of muscarinic receptors, is an ideal antidote for edrophonium.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable