SML3744

Ac-FLTD-CMK

≥95% (HPLC)

• Sinônimo(s): N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone
• Fórmula empírica (Notação de Hill): C₂₆H₃₇ClN₄O₈
• Número CAS: 2376255-48-8
• Peso molecular: 569.05
• Número MDL: MFCD32874101
• Código UNSPSC: 51111800
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: (Powder or Lyophilized powder or film)
• condição de armazenamento: desiccated
• cor: white to off-white
• temperatura de armazenamento: -10 to -25°C

Descrição

Ações bioquímicas/fisiológicas

Ac-FLTD-CMK is a selective gasdermin D (GSDMD) clevage inhibitor (IC50 = 46.7 nM, 329 nM, 1.49 μM, respectively, against GSDMD clevage by human caspase-1, -5, -4 in cell-free enzymatic assays) that suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages (10 μM 4h post 200 ng/mL LPS and 0.5h before ATP or nigericin). Ac-FLTD-CMK selectively blocks GSDMD clevage by inflammatory caspases without affecting apoptotic caspases (caspase-3 IC50 >100 μM) or apoptosis.

Selective gasdermin D (GSDMD) clevage inhibitor that suppresses NLRP3 inflammasome activation and downstream pyroptosis.

Atenção

Hygroscopic

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable