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O9639

Sigma-Aldrich

Oridonin

≥98% (HPLC), solid

Sinônimo(s):

7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one, Isodonol

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About This Item

Fórmula empírica (Notação de Hill):
C20H28O6
Número CAS:
28957-04-2
Peso molecular:
364.43
Código UNSPSC:
12352200
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

solid

solubilidade

DMSO: >20 mg/mL
H2O: insoluble

temperatura de armazenamento

2-8°C

InChI

1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1

chave InChI

SDHTXBWLVGWJFT-XKCURVIJSA-N

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Ações bioquímicas/fisiológicas

Oridonin has potent anti-tumor activity. Oridonin targets AE (AML1-ETO) oncoprotein. Exposure to oridonin induces apoptosis in AE-bearing leukemic cells through the activation of intrinsic apoptotic pathway and triggering a caspase-3-mediated degradation of AE at D188. The compound also prolonged the lifespan of C57 mice bearing truncated AE-expressing leukemic cells without side effects like suppression of bone marrow or reduction of body weight of animals, and exerted synergic effects while combined with cytosine arabinoside. Additionally, oridonin inhibited tumor growth in nude mice inoculated with t(8;21)-harboring Kasumi-1 cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Dimetilsulfóxido Hybri-Max™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

D2650

Dimetilsulfóxido

Dandan Zheng et al.
Drug delivery, 19(6), 286-291 (2012-08-30)
Oridonin (ORI)-loaded Nanostructured lipid carriers (NLC) were prepared by emulsion-evaporation and low temperature-solidification technique, and evaluated for morphological observation, particle size, zeta potential and in vitro drug release. Next, the characteristics of biodistribution and pharmacokinetics in vivo were examined. The
Shan Zhao et al.
Zhongguo shi yan xue ye xue za zhi, 20(3), 611-615 (2012-06-29)
The aim of this study was to investigate the biological effect of longikaurin A on multiple myeloma H929 cells. Effects of oridonin and longikaurin A on proliferation of H929 cells were evaluated by CCK-8 assay. Cell morphological features of H929
Bo Yin et al.
International journal of clinical and experimental pathology, 5(6), 562-568 (2012-09-06)
Many studies have shown that oridonin, a compound purified from Rabdosia rubescens, was able to suppress proliferation and induce apoptosis in many cell types. In this study, In order to investigate the proliferation suppression and apoptosis-inducing effect of oridonin on
Sha Yi et al.
International journal of molecular medicine, 30(4), 877-883 (2012-07-25)
Oridonin has been utilized for the treatment of various human diseases due to its anti-inflammatory, antibacterial and antitumor effects. However, the precise mechanisms induced by oridonin in human erythroleukemia are yet to be clarified. The present study aimed to elucidate
Dandan Zheng et al.
International journal of pharmaceutics, 436(1-2), 379-386 (2012-06-27)
In this study, oridonin-loaded nanoparticles coated with galactosylated chitosan (ORI-GC-NP) were prepared for tumor targeting and their characteristics were evaluated for the morphologies, particle size and zeta potential. Oridonin-loaded nanoparticles (ORI-NP) without galactosylated chitosan were prepared as a control. The
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