SML3362

YM-244769 dihydrochloride

≥98% (HPLC)

• Sinônimo(s): N-​[(3-​Aminophenyl)​methyl]​-​6-​[4-​[(3-​fluorophenyl)​methoxy]​phenoxy]​-3-​pyridinecarboxamide dihydrochloride, N-(3-Aminobenzyl)-6-{4-[3-fluorobenzyl)oxy]phenoxy} nicotinamide dihydrochloride
• Fórmula empírica (Notação de Hill): C₂₆H₂₂FN₃O₃·2HCl
• Número CAS: 1780390-65-9
• Peso molecular: 516.39
• Número MDL: MFCD28160863
• Código UNSPSC: 51111800
• Código UNSPSC: 12352200
• NACRES: NA.21

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to pink
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: -10 to -25°C
• cadeia de caracteres SMILES: O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4
• InChI: 1S/C26H22FN3O3/c27-21-5-1-4-19(13-21)17-32-23-8-10-24(11-9-23)33-25-12-7-20(16-29-25)26(31)30-15-18-3-2-6-22(28)14-18/h1-14,16H,15,17,28H2,(H,30,31)
• chave InChI: JZMLHJRKSJXARY-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3

YM-244769 hydrochloride is a potent and selective inhibitor of Na+/Ca2+ exchange (NCX) acting preferentially at NCX3. It inhibits the Ca2+ entry mode of NCX more potently than the Ca2+ exit mode. YM-244769 exhibits protection in various hypoxic/ischemic cell injury models with low cell toxicity.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable