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SML3331

Sigma-Aldrich

Triheptanoin

≥95% (HPLC)

Sinônimo(s):

Dermofeel TC 7, Glycerol trienanthate, Glyceryl triheptanoate, Heptanoic acid, 1,1′,1′′-(1,2,3-propanetriyl) ester, Heptanoic acid, 1,2,3-propanetriyl ester (9CI), Heptanoin, tri- (6CI,7CI,8CI), Lanol 37T, Trienanthoin, Triheptanoic glyceride, Trioenanthoin, UX007

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About This Item

Fórmula empírica (Notação de Hill):
C24H44O6
Número CAS:
620-67-7
Peso molecular:
428.60
Número MDL:
MFCD00042910
Código UNSPSC:
23201100
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥95% (HPLC)

Formulário

oil

cor

colorless to brown

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O(C(COC(=O)CCCCCC)COC(=O)CCCCCC)C(=O)CCCCCC

InChI

1S/C24H44O6/c1-4-7-10-13-16-22(25)28-19-21(30-24(27)18-15-12-9-6-3)20-29-23(26)17-14-11-8-5-2/h21H,4-20H2,1-3H3

chave InChI

PJHKBYALYHRYSK-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

Orally available triglyceride that provides 3 molar eq of saturated heptanoic acid in vivo to replenish reduced tricarboxylic acid (TCA; Krebs)-cycle intermediates.
Triheptanoin is a triglyceride with 3 molar eq. of saturated heptanoic acid (C7:0). The even-chain FA does not occur naturally and is able to bypass metabolic block induced by enzyme deficiency and to replenish reduced tricarboxylic acid/TCA-cycle (Krebs cycle or citric acid cycle/CAC) intermediates (anaplerosis) in vivo.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

404.6 °F - open cup

Ponto de fulgor (°C)

207 °C - open cup

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Certificados de análise (COA)

Lot/Batch Number

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Ingrid Sofia Vieira de Melo et al.
Nutricion hospitalaria, 32(1), 265-269 (2015-08-12)
the aim of this study was to evaluate the influence of consumption of a ketogenic diet supplemented with triheptanoin, a medium-chain anaplerotic triacylglycerol, on the liver fatty acid profile of Wistar rats. three groups of male Wistar rats (n =
Keri J Fogle et al.
Molecular genetics and metabolism, 126(4), 439-447 (2019-01-27)
Seizures are a feature not only of the many forms of epilepsy, but also of global metabolic diseases such as mitochondrial encephalomyopathy (ME) and glycolytic enzymopathy (GE). Modern anti-epileptic drugs (AEDs) are successful in many cases, but some patients are
Kah Ni Tan et al.
Journal of neurochemistry, 144(4), 431-442 (2017-12-10)
Triheptanoin, the triglyceride of heptanoate, is anaplerotic (refills deficient tricarboxylic acid cycle intermediates) via the propionyl-CoA carboxylase pathway. It has been shown to be neuroprotective and anticonvulsant in several models of neurological disorders. Here, we investigated the effects of triheptanoin
Giovanna Testa et al.
Neuropharmacology, 148, 305-310 (2019-01-15)
The Forkhead Box G1 (FOXG1) gene encodes a transcription factor with an essential role in mammalian telencephalon development. FOXG1-related disorders, caused by deletions, intragenic mutations or duplications, are usually associated with severe intellectual disability, autistic features, and, in 87% of
Tanya McDonald et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 40(3), 678-691 (2019-03-21)
Triheptanoin is anticonvulsant in several seizure models. Here, we investigated changes in glucose metabolism by triheptanoin interictally in the chronic stage of the pilocarpine mouse epilepsy model. After injection of [U-13C6]-glucose (i.p.), enrichments of 13C in intermediates of glycolysis and

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