SML3315

PF-07304814

≥98% (HPLC)

• Sinônimo(s): (S)-3-((S)-2-(4-Methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl dihydrogen phosphate, 4-Methoxy-N-[(1S )-3-methyl-1-[[[(1S )-2-oxo-1-[[(3S )-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]-1H-indole-2-carboxamide, PF 007304814, PF 00835231 phosphate prodrug, PF 07304814, PF 835231 phosphate prodrug, PF-007304814, PF-835231 phosphate prodrug, PF007304814, PF07304814, PF835231 phosphate prodrug
• Fórmula empírica (Notação de Hill): C₂₄H₃₃N₄O₉P
• Número CAS: 2468015-78-1
• Peso molecular: 552.51
• Número MDL: MFCD33029313
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C

Descrição

Ações bioquímicas/fisiológicas

PF-07304814 is a non-cytotoxic, aqueous soluble phosphate ester prodrug of the potent and selective corona virus inhibitor PF-00835231 (pro-/active drug SARS CoV-2 Ki = 174/0.27 nM). PF-07304814 is rapidly converted to PF-00835231, exhibiting anti-viral efficacy in cultures (PF-07304814/PF-00835231 IC50 with 2 μM P-pg efflux inhibitor CP-100356 = 3.8/0.24 μM (SARS2 Washington 1 & Vero E6-enACE2), 830/760 nM (SARS2 BetaCov GHB-03021/2020 & Vero E6-EGFP); PF-07304814/PF-00835231 IC50 with 0.5 μM CP-100356 = 58/80 nM (HCoV-229E & MRC-5)) without affecting P450 enzymes (>100 μM) or a range of transporters (>130 μM).

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable