SML3230

VU0360172 hydrochloride

≥98% (HPLC)

• Sinônimo(s): N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide hydrochloride
• Fórmula empírica (Notação de Hill): C₁₈H₁₅FN₂O · HCl
• Número CAS: 1309976-62-2
• Peso molecular: 330.78
• Número MDL: MFCD22683808
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear (warmed)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: FC1=CC=CC(C#CC2=NC=C(C=C2)C(NC3CCC3)=O)=C1.Cl
• InChI: 1S/C18H15FN2O.ClH/c19-15-4-1-3-13(11-15)7-9-16-10-8-14(12-20-16)18(22)21-17-5-2-6-17;/h1,3-4,8,10-12,17H,2,5-6H2,(H,21,22);1H
• chave InChI: NBGAPTWZQXSEAA-UHFFFAOYSA-N

Descrição

Descrição geral

VU0360172 is a potent (EC50 = 16.6 nM), systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic model, producing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce spontaneous absence seizures in WAG/Rij rats and to inhibit pain. Reduced spontaneous spike and wave discharges without impacting motor behavior in a rat model of absence epilepsy have been observed.

Ações bioquímicas/fisiológicas

VU0360172 is a potent (EC50 = 16.6 nM), systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic model, producing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce absence seizures in WAG/Rij rats and to inhibit pain.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable