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SML2690

Sigma-Aldrich

Pyridostatin hydrochloride

≥98% (HPLC), powder, G-quadruplex DNA stabilizing agent

Sinônimo(s):

4-(2-Aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide hydrochloride, 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide hydrochloride, RR 82 HCl, RR-82 HCl, RR82 HCl

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About This Item

Fórmula empírica (Notação de Hill):
C31H32N8O5 · xHCl
Peso molecular:
596.64 (free base basis)
Número MDL:
MFCD25976689
Código UNSPSC:
12352200
NACRES:
NA.77

Nome do produto

Pyridostatin hydrochloride, ≥98% (HPLC)

Ensaio

≥98% (HPLC)

Formulário

powder

condição de armazenamento

desiccated

cor

white to beige

solubilidade

DMSO: 2 mg/mL, clear

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

NCCOc1cc(nc(c1)C(=O)Nc4nc5c(c(c4)OCCN)cccc5)C(=O)Nc2nc3c(c(c2)OCCN)cccc3

chave InChI

VGHSATQVJCTKEF-UHFFFAOYSA-N

Aplicação

Pyridostatin hydrochloride has been used as a G-quadruplex (G4)-stabilizing ligand to check the effect of G4s on fork progression. It has also been used as a G4-stabilizing ligand to study the effect of G4 on apurinic/apyrimidinic endonuclease 1 (APE1) mediated Kirsten rat sarcoma virus (KRAS) expression in pancreatic ductal adenocarcinoma (PDAC) cell lines.

Ações bioquímicas/fisiológicas

Pyridostatin is a highly selective G-quadruplex (G4) interacting molecule. It retards the growth of human cancer cells by inducing replication/transcription dependent on DNA damage. Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G4, inducing DNA damage and cell-cycle arrest.
Stabilizer of G-quadruplexes (G4).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Hong-Liang Bao et al.
Nature protocols, 13(4), 652-665 (2018-03-09)
Growing evidence indicates that RNA G-quadruplexes have important roles in various processes such as transcription, translation, regulation of telomere length, and formation of telomeric heterochromatin. Investigation of RNA G-quadruplex structures associated with biological events is therefore essential to understanding the
Alessio De Magis et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(3), 816-825 (2018-12-29)
G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic nuclear processes and trigger DNA damage, genome instability, and cell killing. By different technical approaches, we here establish that specific G4 ligands stabilize G4s and simultaneously
Claudia Ribeiro de Almeida et al.
Molecular cell, 70(4), 650-662 (2018-05-08)
Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions. While these often occur co-transcriptionally between nascent RNA and template DNA, we now show that they also form

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