SML1476

Thiocolchicoside

≥98% (HPLC)

• Sinônimo(s): (S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide, 2-Demethoxy-2-glucosidoxythiocolchicine
• Fórmula empírica (Notação de Hill): C₂₇H₃₃NO₁₀S
• Número CAS: 602-41-5
• Peso molecular: 563.62
• Número CE: 210-017-7
• Número MDL: MFCD07995056
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825907
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D -510 to -610°, c = 0.5 in H₂O
• cor: light yellow to dark yellow
• solubilidade: H₂O: 10 mg/mL, clear
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O
• InChI: 1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
• chave InChI: LEQAKWQJCITZNK-AXHKHJLKSA-N

Descrição

Ações bioquímicas/fisiológicas

Thiocolchicoside acts as a muscle relaxant. In experimental animals, thiocolchicoside results in malfunctions (teratogenic) and impairs chromosomes. It is advised to be used as an analgesic for patients with muscle pain, starting with paracetamol. Thiocolchicoside can be used in irrigation solution at the time of endoscopic treatment of ureteral calculus to reduce the movement of stones.

Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301,H341,H361fd,H372
• Declarações de precaução: P201 - P301 + P310 + P330
• Classificações de perigo: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Órgãos-alvo: Gastro-intestinal system
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable