SML1170

SR2211

≥98% (HPLC)

• Sinônimo(s): 1,1,1,3,3,3-Hexafluoro-2-(2-fluoro-4-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1-biphenyl]-4-yl)propan-2-ol, ;2-Fluoro-4′-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1′-biphenyl]-4-methanol, ML310
• Fórmula empírica (Notação de Hill): C₂₆H₂₄F₇N₃O
• Número CAS: 1359164-11-6
• Peso molecular: 527.48
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 5 mg/mL, clear (warmed)
• temperatura de armazenamento: −20°C
• InChI: 1S/C26H24F7N3O/c27-23-15-21(24(37,25(28,29)30)26(31,32)33)5-6-22(23)20-3-1-18(2-4-20)16-35-11-13-36(14-12-35)17-19-7-9-34-10-8-19/h1-10,15,37H,11-14,16-17H2
• chave InChI: KVHKWAZUPPBMLL-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

SR2211 (ML310) is a potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (RORγ). RORγ is essential for interleukin 17 expression and differentiation of TH17 cells, important in autoimmune diseases including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and lupus. SR2211 (ML310) treatment of EL-4 murine T lymphocyte cells resulted in suppression of gene expression and production of IL-17 with an IC₅₀ ~320 nM with no effect on the transcriptional activity of RORγ. In a mouse model of rheumatoid arthritis, SR2211 significantly reduced joint inflammation, suppressing inflammatory T cell function, expression and production of inflammatory cytokines, and macrophage activation.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable