SML1139

Rostafuroxin

≥98% (HPLC)

• Sinônimo(s): (3,5,14)-21,23-epoxy24-Norchola-20,22-diene-3,14,17-triol, PST 2238
• Fórmula empírica (Notação de Hill): C₂₃H₃₄O₄
• Número CAS: 156722-18-8
• Peso molecular: 374.51
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 20 mg/mL, clear
• temperatura de armazenamento: −20°C
• InChI: 1S/C23H34O4/c1-20-8-5-17(24)13-15(20)3-4-19-18(20)6-9-21(2)22(25,10-11-23(19,21)26)16-7-12-27-14-16/h7,12,14-15,17-19,24-26H,3-6,8-11,13H2,1-2H3/t15-,17+,18+,19-,20+,21-,22+,23+/m1/s1
• chave InChI: AEAPORIZZWBIEX-DTBDINHYSA-N

Descrição

Ações bioquímicas/fisiológicas

Rostafuroxin is a derivative of digitoxigenin. It protects animal models against podocyte lesions and proteinuria by counteracting mutant β-adducin and ouabain-mediated effects.

Rostafuroxin is a digitoxygenin derivative that selectively antagonizes the effects of endogenous ouabain on the Na⁺,K⁺-ATPase, which maintains sodium and potassium ion gradients across plasma membranes. Rostafuroxin lowers blood pressure (BP) in animal models of hypertension.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable