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SML1075

Sigma-Aldrich

Atglistatin

≥98% (HPLC), powder, adipose triglyceride lipase inhibitor

Sinônimo(s):

3-(4′-(Dimethylamino)-[1,1′-biphenyl]-3-yl)-1,1-dimethylurea

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About This Item

Fórmula empírica (Notação de Hill):
C17H21N3O
Número CAS:
1469924-27-3
Peso molecular:
283.37
Número MDL:
MFCD28009494
Código UNSPSC:
12352200
ID de substância PubChem:
329825457
NACRES:
NA.77

Nome do produto

Atglistatin, ≥98% (HPLC)

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 20 mg/mL, clear

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CN(C)C(NC1=CC=CC(C2=CC=C(N(C)C)C=C2)=C1)=O

InChI

1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)

chave InChI

AWOPBSAJHCUSAS-UHFFFAOYSA-N

Aplicação

Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL).

Ações bioquímicas/fisiológicas

Atglistatin is a selective inhibitor of adipose triglyceride lipase (ATGL).
Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC50 of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.

Outras notas

Produced under the license of University of Graz/Graz University of Technolog

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
116M4703V
104M4719V

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