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Key Documents

SML0998

Sigma-Aldrich

AdipoRon

≥98% (HPLC)

Sinônimo(s):

2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-acetamide, AdipoR agonist

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About This Item

Fórmula empírica (Notação de Hill):
C27H28N2O3
Número CAS:
924416-43-3
Peso molecular:
428.52
Código UNSPSC:
51111800
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

cor

white to beige

solubilidade

DMSO: 10 mg/mL, clear

temperatura de armazenamento

room temp

InChI

1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)

chave InChI

SHHUPGSHGSNPDB-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

AdipoRon is an adiponectin agonist that binds to and activates adiponectin receptors AdipoR1 and AdipoR2, activating AMPK and PPAR-α pathways, and ameliorating insulin resistance and glucose intolerance in mice fed a high-fat diet in a manner similar to adiponectin itself. AdipoRon did not affect body weight, but did increase the expression of genes involved in fatty-acid oxidation, decreased tissue triglyceride content, and prolonged the shortened lifespan of db/db mice.
Oral administration of adipoRon reduced postischemic oxidative stress showing lower expression of NADPH (Nicotinamide adenine diphosphate) oxidase and superoxide production in mouse model. Hence, adipoRon might be considered as a cardioprotective molecule.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sonja Lindfors et al.
Diabetologia, 64(8), 1866-1879 (2021-05-15)
Chronic low-grade inflammation with local upregulation of proinflammatory molecules plays a role in the progression of obesity-related renal injury. Reduced serum concentration of anti-inflammatory adiponectin may promote chronic inflammation. Here, we investigated the potential anti-inflammatory and renoprotective effects and mechanisms
AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings.
Zhang Y, et al.
American Journal of Physiology. Endocrinology and Metabolism, 309(3), E275-E282 (2015)
Maria Lorena Oróstica et al.
International journal of molecular sciences, 23(7) (2022-04-13)
Polycystic ovary syndrome (PCOS) is an endocrine/metabolic disorder associated with insulin resistance (IR) and obesity. Endometria from women with PCOS present failures in insulin action, glucose uptake and signaling of insulin-sensitizing molecules, such as adiponectin, with consequences for reproduction. Metformin
Angela Ragone et al.
Frontiers in pharmacology, 13, 837503-837503 (2022-03-12)
Pancreatic ductal adenocarcinoma (PDAC) accounts for 90% of all pancreatic cancers. Albeit its incidence does not score among the highest in cancer, PDAC prognosis is tremendously fatal. As a result of either aggressiveness or metastatic stage at diagnosis, chemotherapy constitutes
Michael L Salinas et al.
Biophysical journal, 118(4), 885-897 (2019-10-22)
The increasing prevalence of adult and adolescent obesity and its associated risk of colorectal cancer reinforces the urgent need to elucidate the underlying mechanisms contributing to the promotion of colon cancer in obese individuals. Adiponectin is an adipose tissue-derived adipokine
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