SML0854

TBCA

≥98% (HPLC)

• Sinônimo(s): (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, Tetrabromocinnamic acid
• Fórmula empírica (Notação de Hill): C₉H₄Br₄O₂
• Número CAS: 934358-00-6
• Peso molecular: 463.74
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 20 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Brc1c(c(cc(c1Br)\C=C\C(=O)O)Br)Br
• InChI: 1S/C9H4Br4O2/c10-5-3-4(1-2-6(14)15)7(11)9(13)8(5)12/h1-3H,(H,14,15)/b2-1+
• chave InChI: SVJQCVOKYJWUBC-OWOJBTEDSA-N

Descrição

Aplicação

Tetrabromocinnamic acid (TBCA) has been used in protein-fragment complementation assay, in an approach to identify inhibitors of αsyn oligomerization.

Ações bioquímicas/fisiológicas

Tetrabromocinnamic acid (TBCA) is a selective casein kinase CK2 inhibitor.

Tetrabromocinnamic acid (TBCA) is a selective cell-permeable ATP-competitive casein kinase CK2 inhibitor with an IC₅₀ of 110 nM, 2-fold selectivity over CK1, and with the advantage of being less active on DYRK1A (IC₅₀ = 24.5 μM) than other CK2 inhibitors suh as DMAT. Elevated levels of CK2 are associated with many cancers and also with tau hyperphosphorylation and neuropathology found in Alzheimer′s disease and other neurodegenerative disorders. In prostate cancer cells TBCA reduced cell proliferation and caused G2/M cell cycle arrest. In isolated squid axoplasms, TBCA also blocked inhibition of fast axonal transport by Aβ oligomers.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2