SML0474

(S)-Duloxetine hydrochloride

≥98% (HPLC)

• Sinônimo(s): (γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride, (+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride, (+)-N-Methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, LY-248686 hydrochloride
• Fórmula empírica (Notação de Hill): C₁₈H₁₉NOS · HCl
• Número CAS: 136434-34-9
• Peso molecular: 333.88
• Número MDL: MFCD06407958
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825429
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D +116 to +125°, c = 1 in methanol
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: H₂O: 5 mg/mL (clear solution, warmed)
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: Cl.CNCC[C@H](Oc1cccc2ccccc12)c3cccs3
• InChI: 1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1
• chave InChI: BFFSMCNJSOPUAY-LMOVPXPDSA-N
• Informações sobre genes: human ... SLC6A2(6530) , SLC6A4(6532)

Descrição

Descrição geral

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. Duloxetine is a thiophene derivative. It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP). Duloxetine is a cytochrome P450 2D6 (CYP2D6) inhibitor.

Aplicação

(S)-Duloxetine hydrochloride has been used as an antidepressant in rats exposed to chronic mild stress (CMS).

Ações bioquímicas/fisiológicas

Duloxetine hydrochloride is a dual serotonin/norepinephrine reuptake inhibitor (SNRI), widely used clinically as an antidepressant and anxiolytic.

Características e benefícios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Atenção

air sensitive

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable