SML0283

Amorolfine hydrochloride

≥98% (HPLC)

• Sinônimo(s): (2R,6S)-rel-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine hydrochloride, Ro 14-4767/002
• Fórmula empírica (Notação de Hill): C₂₁H₃₅ON · HCl
• Número CAS: 78613-38-4
• Peso molecular: 353.97
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825291
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: DMSO: ≥5 mg/mL (warmed)
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: Cl.CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1
• InChI: 1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
• chave InChI: XZKWIPVTHGWDCF-KUZYQSSXSA-N

Descrição

Aplicação

Amorolfine hydrochloride has been used as an antifungal agent.

Ações bioquímicas/fisiológicas

Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation.

Amorolfine hydrochloride is a potential for treating onychomycosis infected nails by topical application. A 5% solution combination with fluconazole is effective on sensitive fungus in fingernail onychomycosis.

Amorolfine is a broad-based antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts.

Informações de segurança

• Pictogramas: GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H302,H315,H411
• Declarações de precaução: P264 - P273 - P280 - P301 + P312 - P302 + P352 - P332 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable