SBR00002

Arzanol

from Helichrysum italicum, ≥98%

• Sinônimo(s): 3-[[3-Acetyl-2,4,6-trihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]methyl]-6-ethyl-4-hydroxy-5-methyl-2H-pyran-2-one
• Fórmula empírica (Notação de Hill): C₂₂H₂₆O₇
• Número CAS: 32274-52-5
• Peso molecular: 402.44
• Número MDL: MFCD28168041
• Código UNSPSC: 12352200
• ID de substância PubChem: 329824643
• NACRES: NA.25

Propriedades

• fonte biológica: Helichrysum italicum
• Nível de qualidade: 200
• Ensaio: ≥98%
• forma: powder
• aplicação(ões): metabolomics; vitamins, nutraceuticals, and natural products
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OC1=C(CC2=C(O)C(C)=C(CC)OC2=O)C(O)=C(C(C)=O)C(O)=C1CC=C(C)C
• InChI: 1S/C22H26O7/c1-6-16-11(4)18(24)15(22(28)29-16)9-14-19(25)13(8-7-10(2)3)20(26)17(12(5)23)21(14)27/h7,24-27H,6,8-9H2,1-5H3
• chave InChI: ZOIAPLVBZQQHCG-UHFFFAOYSA-N

Descrição

Descrição geral

Arzanol is a pyrone–phloroglucinol etherodimer. It is a polyphenol compound extracted from the plant Helichrysum italicum which grows in the Mediterranean area.

Aplicação

Arzanol has been used to test its effects as an autophagy modulator on HeLa cells and bladder cancer cells

Ações bioquímicas/fisiológicas

Arzanol is a polyphenol compound extracted from the plant Helichrysum italicum which grows in the Mediterranean area. Arzanol is known for its anti-inflammatory and antimicrobial activities. The anti-inflammatory activity was verified in an in-vivo rat model and was found to suppress the inflammatory response of the carrageenan-induced pleurisy. Moreover it was found to have an anti-HIV-1 activity. Arzanol inhibits COX-2-derived prostaglandin synthase-1 (mPGES-1) Inhibitor in-vitro, in human stimulated monocytes.
Arzanol inhibits the activation of inflammatory transcription factor NFκB, HIV replication in T cells, releases of IL-1β, IL-6, IL-8, and TNF-α,and biosynthesis of PGE2 by potentially inhibiting the mPGES-1 enzyme.

Arzanol is known for its anti-inflammatory and antimicrobial activities. The anti-inflammatory activity was verified in an in-vivo rat model and was found to suppress the inflammatory response of the carrageenan-induced pleurisy. Moreover it was found to have an anti-HIV-1 activity. Arzanol inhibits COX-2-derived prostaglandin synthase-1 (mPGES-1) Inhibitor in-vitro, in human stimulated monocytes.
Arzanol inhibits the activation of inflammatory transcription factor nuclear factor-KB (NF-KB), human immunodeficiency virus (HIV) replication in T cells, releases of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α and biosynthesis of prostaglandin E2 (PGE2) by potentially inhibiting the mPGES-1 enzyme. It also possesses antioxidant and cytotoxic activity.

Reconstituição

Soluble in dimethyl sulfoxide (DMSO) at 1 mg/mL; poorly soluble in water

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable