SAB5701928

Anti-Phospho-MLKL-S454 antibody produced in rabbit

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: liquid
• reatividade de espécies: human, mouse
• concentração: 0.464 mg/mL
• técnica(s): western blot: 1:500-1:2000
• nº de adesão UniProt: Q8NB16
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pSer454)
• Informações sobre genes: human ... Phospho-MLKL-S454(197259)

Descrição

Descrição geral

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Imunogênio

A phospho synthetic peptide corresponding to residues surrounding S454 of human MLKL.

forma física

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable