SAB5700439

Anti-Phospho-NR3C1-S211 antibody produced in rabbit

• Sinônimo(s): GCCR, GCR, GCRST, GR, GRL, NR3C1
• Código UNSPSC: 12352203
• NACRES: NA.43
• clone: polyclonal
• application: WB
• reatividade de espécies: human
• técnica(s): western blot: 1:1000-1:2000

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: 49-85
• reatividade de espécies: human
• concentração: 1.02 mg/ml
• técnica(s): western blot: 1:1000-1:2000
• nº de adesão UniProt: P04150
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pSer211)
• Informações sobre genes: human ... NR3C1(2908)

Descrição

Descrição geral

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

Imunogênio

A synthetic phosphorylated peptide around S211 of human NR3C1 (NP_000167.1).

forma física

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Armazenamento e estabilidade

Store at -20℃. Avoid freeze / thaw cycles.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable