SAB5500014
Anti-BCL-2 Alpha antibody, Rabbit monoclonal
recombinant, expressed in proprietary host, clone SP66, affinity isolated antibody
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
recombinante
expressed in proprietary host
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
SP66, monoclonal
reatividade de espécies
human (tested)
técnica(s)
flow cytometry: 1:100
immunohistochemistry: 1:100
Isotipo
IgG
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... BCL2(596)
Descrição geral
B-cell lymphoma 2 (BCL-2) is an anti-apoptotic and target gene of nuclear factor-κB (NF-κB). The protein is expressed in the nuclear envelope, mitochondria and endoplasmic reticulum. The gene encoding BCL-2 is localized on human chromosome 18q21.
Imunogênio
Synthetic peptide corresponding to N-terminus of human BCL-2 alpha protein.
Ações bioquímicas/fisiológicas
B-cell lymphoma 2 (BCL-2) inhibits apoptosis in cells and has been shown to be upregulated in adenomas. Expression of BCL-2α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2α protein, whereas the normal or hyperplastic germinal centers are negative.
Características e benefícios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
forma física
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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recomendado
Nº do produto
Descrição
Preços
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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P. Riederer
Advances in Research on Neurodegeneration null
Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
Portier BP and Taglialatela G
The Journal of Biological Chemistry, 281(52), 40493-40502 (2006)
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.
Stornaiuolo M
Journal of Medicinal Chemistry, 58(5), 2135-2148 (2015)
Maartje van der Heijden et al.
Nature communications, 7, 10916-10916 (2016-03-10)
Intestinal tumour formation is generally thought to occur following mutational events in the stem cell pool. However, active NF-κB signalling additionally facilitates malignant transformation of differentiated cells. We hypothesized that genes shared between NF-κB and intestinal stem cell (ISCs) signatures
Xiaopeng Wang et al.
Molecular medicine reports, 23(2) (2020-12-11)
Acute progressive hypoxic respiratory failure caused by various predisposing factors is known as acute respiratory distress syndrome (ARDS). Although penehyclidine hydrochloride (PHC), an anticholinergic drug, is widely applied in clinical practice, the specific mechanisms underlying PHC in the treatment of
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