SAB5200020

Monoclonal Anti-MDC1 antibody produced in mouse

clone P2B11, 1 mg/mL, purified immunoglobulin

• Sinônimo(s): Anti-MDC1, P2B11, Anti-Nuclear factor with BRCT domains1, Anti-mediator of DNA damage checkpoint 1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• conjugado: unconjugated
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: P2B11, monoclonal
• forma: buffered aqueous glycerol solution
• peso molecular: antigen predicted mol wt 184 kDa
• reatividade de espécies: human, mouse, bovine, chimpanzee
• concentração: 1 mg/mL
• técnica(s): indirect immunofluorescence: suitable; western blot: suitable
• Isotipo: IgG1
• nº de adesão NCBI: NP_001010833.2
• nº de adesão UniProt: Q14676
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: mouse ... MDC1(240087)

Descrição

Descrição geral

Mediator of DNA damage checkpoint 1 (MDC1) is a nuclear protein that in humans is encoded by the MDC1 gene mapped to chromosome 6p21.33. The encoded protein is widely expressed in various types of tissues and organs. MDC1 is characterized with two BRCA1 C terminus (BRCT) domain, an N-terminal phosphoamino-acid-binding motif called a forkhead-associated (FHA) domain and large central proline/serine/threonine-rich repeat (PST) domain.

Especificidade

Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus.

Imunogênio

GST-tagged recombinant protein corresponding to mouse MDC1 ar and around the N-termius

Ações bioquímicas/fisiológicas

Mediator of DNA damage checkpoint 1 (MDC1) plays a vital role in stimulation of the intra–S phase and G2-M phase checkpoints of the cell cycle in response to DNA damage. Polymorphism of the gene has been associated with the development of both the serum LDL-cholesterol concentration and hyper–LDL-cholesterolemia. Mammalian MDC1/ nuclear factor with BRCT domain 1 (NFBD1) interacts with phospho-H2AX (γH2AX) and plays a key role in DNA damage response by facilitating normal radioresistance and efficient accumulation of DNA-damage-response proteins on damaged chromatin.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable