SAB4700215

Monoclonal Anti-CD63 antibody produced in mouse

clone MEM-259, purified immunoglobulin, buffered aqueous solution

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: MEM-259, monoclonal
• Formulário: buffered aqueous solution
• reatividade de espécies: human
• concentração: 1 mg/mL
• técnica(s): flow cytometry: suitable
• Isotipo: IgG1
• nº de adesão NCBI: NM_001040034.1
• nº de adesão UniProt: P08962
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... CD63(967)

Descrição

Descrição geral

Cluster of differentiation 63 (CD63), also known as melanoma 1 antigen, is encoded by the gene mapped to human chromosome 12q13.2. The encoded protein belongs to the transmembrane 4 superfamily (TM4SF). CD63 is an integral membrane glycoprotein expressed in late endosomes and lysosomes and is also present in the platelet dense granule membrane.

The antibody MEM-259 reacts with CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.

Imunogênio

HPB-ALL T cell line

Aplicação

Monoclonal Anti-CD63 antibody produced in mouse has been used in flow cytometry and confocal imaging.

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Ações bioquímicas/fisiológicas

Cluster of differentiation 63 (CD63) is one of the platelet activation marker, which plays a vital role in platelet aggregation, adhesion to collagen, uptake of oxidized low-density lipoprotein (LDL) in vitro and regulation of angiogenesis. Inadequate expression of CD63 results in the autosomal recessive inherited disorder, Hermansky-Pudlak syndrome. CD63 is associated with various cellular functions, such as cellular adhesion, cell differentiation, migration, carcinogenesis and tumor progression. CD63 is highly expressed in the initial stage of Merkel cell carcinoma and decreased in later stages; therefore, CD63 is considered to be a potential prognostic factor for this malignancy.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable