SAB4503071
Anti-Vitamin D Receptor antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
1,25-dihydroxyvitamin D3 receptor, NR1I1, vitamin D receptor, vitamin D3 receptor
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About This Item
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
antigen 48 kDa
reatividade de espécies
human
concentração
~1 mg/mL
técnica(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... VDR(7421)
Descrição geral
Anti-Vitamin D Receptor Antibody detects endogenous levels of total Vitamin D Receptor protein.
Vitamin D receptor (VDR) gene codes for a nuclear receptor. It is expressed at a high level in the hypothalamus and the large neurons of the substantia nigra in the brain. VDR gene comprises 14 exons and 6 untranslated exons with alternative splicing sites. It is mapped to human chromosome 12q13.1.
Imunogênio
The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor.
Immunogen Range: 181-230
Immunogen Range: 181-230
Aplicação
Anti-Vitamin D Receptor antibody produced in rabbit has been used in western blotting and immunofluorescence staining (1:200) (1:100).
Ações bioquímicas/fisiológicas
Vitamin D receptor (VDR) protein modulates genes associated with inflammation, chronic diseases, oxidative damage, and the metabolism of bone. VDR gene is involved in the susceptibility of type 2 diabetes mellitus (T2DM). The nuclear receptor encoded by the VDR gene possesses pluripotent effects. It is capable of specifically binding the elements of DNA response when bound to the ligand. VDR acts as a receptor for 1,25 dihydroxyvitamin D3 (1,25(OH)2 D3). It facilitates the biological activities of vitamin D. Inadequacy of vitamin D is a risk factor for Alzheimer′s disease (AD).
Características e benefícios
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forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
C Del Puerto et al.
The British journal of dermatology, 179(1), 95-100 (2017-11-07)
Vitamin D deficiency is associated with higher risk of cancer, possibly due to its antiproliferative, antiangiogenic, proapoptotic, cell-differentiating and anti-invasive effects. The anticarcinogenic role of vitamin D in melanoma is still a matter of debate. Loss of nuclear and cytoplasmic
Franz J J Rieder et al.
The Journal of steroid biochemistry and molecular biology, 165(Pt B), 356-362 (2016-08-16)
Vitamin D (VD) is essential for the human body and involved in a wide variety of critical physiological processes including bone, muscle, and cardiovascular health, as well as innate immunity and antimicrobial responses. Here, we elucidated the significance of the
Dao-Jun Chen et al.
Oncotarget, 8(37), 62099-62110 (2017-10-06)
Vitamin D has been recognized as a potent immunomodulator and its deficiency is common in different population groups including patients with SLE. As miRNAs regulation plays a significant role in SLE, the present study aimed to evaluate the association between
Issam Francis et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 91(1-2), 124-132 (2019-10-19)
Vitamin D deficiency is an emerging risk factor for breast cancer suggesting its role in breast cancer pathogenesis. Recent evidence suggests vitamin D receptor (VDR) expression is a prognosis predictor in breast cancer. We set out to determine the status
Seong Min Lee et al.
Endocrinology, 155(11), 4137-4148 (2014-08-26)
The syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is a genetic disease of altered mineral homeostasis due to mutations in the vitamin D receptor (VDR) gene. It is frequently, but not always, accompanied by the presence of alopecia. Mouse models
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