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Key Documents

SAB4502580

Sigma-Aldrich

Anti-Retinoic Acid Receptor α antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

NR1B1, Nuclear receptor subfamily 1 group B member 1, RAR-α, RARA, Retinoic acid receptor α

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About This Item

Número MDL:
MFCD00802878
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 50 kDa

reatividade de espécies

human, mouse, rat

concentração

~1 mg/mL

técnica(s)

ELISA: 1:10000
western blot: 1:500-1:1000

nº de adesão NCBI

P10276

nº de adesão UniProt

P10276

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... RARA(5914)

Descrição geral

Anti-Retinoic Acid Receptor α Antibody detects endogenous levels of total Retinoic Acid Receptor α protein.
Retinoic acid receptor α (RARα) is a nuclear receptor for retinoic acid and is expressed in the retina. It belongs to the nuclear steroid/thyroid hormone receptor superfamily. The gene encoding it is localized on human chromosome 17q21.

Imunogênio

The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor alpha.

Immunogen Range: 46-95

Ações bioquímicas/fisiológicas

Retinoic acid receptor α (RARα) is a ligand-dependent transcriptional modulator of genes that has a role in differentiation, cellular development and apoptosis. It has a role in germ-cell development in testis. The protein may be associated with acute promyelocytic leukemia.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures.
Doi A
Molecular Oncology, 9(2), 355-364 (2015)
Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.
Santos NC and Kim KH
Endocrinology, 151(5), 2361-2372 (2010)
The retinoic acid receptor alpha (RARA) gene is not associated with myopia, hypermetropia, and ocular biometric measures.
Veerappan S
Molecular Vision, 15, 1390-1397 (2009)
NLS-RARa promotes proliferation and inhibits differentiation in HL-60 cells.
Hu XX
International Journal of Medical Sciences, 11(3), 247-254 (2014)
Kohichi Kawahara et al.
Journal of Alzheimer's disease : JAD, 42(2), 587-605 (2014-06-12)
Alzheimer's disease (AD) is a neurodegenerative process involving amyloid-β (Aβ) peptide deposition, neuroinflammation, and progressive memory loss. Here, we evaluated whether oral administration of retinoic acid receptor (RAR)α,β agonist Am80 (tamibarotene) or specific retinoid X receptor (RXR) pan agonist HX630

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