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Key Documents

SAB4501746

Sigma-Aldrich

Anti-Galectin 3 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

35 kDa lectin, CBP 35, Carbohydrate binding protein 35, GALBP, Galactose-specific lectin 3

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About This Item

Número MDL:
MFCD01633374
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 26 kDa

reatividade de espécies

rat, human, mouse

concentração

~1 mg/mL

técnica(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

P17931

nº de adesão UniProt

P17931

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... LGALS3(3958)

Categorias relacionadas

Descrição geral

Anti-Galectin 3 Antibody detects endogenous levels of total Galectin 3 protein.
Galectin 3 is a carbohydrate-binding protein. It is abundantly expressed in the extracellular matrix, the cytoplasm and the nucleus. It contains an intrinsically disordered N-terminal domain and a canonical CRD (carbohydrate recognition domain). It is mapped to human chromosome 14q22.

Imunogênio

The antiserum was produced against synthesized peptide derived from human Galectin 3.

Immunogen Range: 141-190

Ações bioquímicas/fisiológicas

Galectin 3 controls cell activation, migration, adhesion and signaling. It plays a role in cancer progression after it is initiated. Expression of galectin-3 regulates apoptosis and development of T-cell. It participates in several physiological and pathological processes like pre-mRNA splicing, neoplastic transformation and immune responses.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

LGALS3 (lectin, galactoside-binding, soluble, 3).
Nangia-Makker P, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15(6) (2011)
Ping-Ping Lang et al.
Laboratory investigation; a journal of technical methods and pathology, 100(3), 378-386 (2019-09-19)
Monocyte and adhesion infiltration into the arterial subendothelium are initial steps in hypertension development. The endothelial intercellular adhesion molecule-1 (ICAM-1) has been implicated in the recruitment and adhesion of leukocytes in several cardiac diseases. However, the role of ICAM-1 in
The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions.
Lin YH, et al.
The Journal of Biological Chemistry, 292(43), 17845-17856 (2017)
Expression of galectin-3 modulates T-cell growth and apoptosis.
Yang RY, et al.
Proceedings of the National Academy of Sciences of the USA, 93(13), 6737-6742 (1996)
József Murányi et al.
International journal of molecular sciences, 20(22) (2019-11-14)
Several promising anti-cancer drug-GnRH (gonadotropin-releasing hormone) conjugates have been developed in the last two decades, although none of them have been approved for clinical use yet. Crizotinib is an effective multi-target kinase inhibitor, approved against anaplastic lymphoma kinase (ALK)- or
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