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Documentos Principais

SAB4501658

Sigma-Aldrich

Anti-Keratin 15 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

CK-15, Cytokeratin-15, K15, Keratin type I cytoskeletal 15

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

peso molecular

antigen 49 kDa

reatividade de espécies

mouse, rat, human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... KRT15(3866)

Descrição geral

Anti-Keratin 15 Antibody detects endogenous levels of total Keratin 15 protein.
Keratin 15 (KRT15)/cytokeratin 15, a type I keratin, belongs to the keratin (KRT) gene family. It is expressed in basal keratinocytes of stratified epithelium. KRT15 gene is located on human chromosome 17q21.2. Anti-Keratin 15 antibody detects endogenous levels of total Keratin 15 protein.

Imunogênio

The antiserum was produced against synthesized peptide derived from human Keratin 15.

Immunogen Range: 1-50

Aplicação

Anti-Keratin 15 antibody produced in rabbit has been used in: immunohistochemistry (1:100), immunofluorescence (1:100), immunostaining

Ações bioquímicas/fisiológicas

Keratin 15 (KRT15) participates in maintaining cytoplasmic stability. It acts as a marker for skin stem cells in the hair follicle bulge. KRT15 plays a major role in epidermal homeostasis. It is associated with tumorigenesis. KRT15 might serve as a biomarker in predicting the prognosis of breast invasive carcinoma (BRCA) patients. Overexpression of the KRT15 gene is seen in squamous-cell carcinoma.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Development of the human prostate
Cunha GR, et al.
Differentiation, 103, 24-45 (2018)
X Rao et al.
Neoplasma, 67(2), 410-414 (2019-12-31)
Keratin-15 (KRT15) is a type I keratin lacking a defined type II partner and plays a key role in maintaining cytoplasmic stability. Recently, studies have reported that KRT15 was correlated with tumor formation and progression. However, the clinical significance of
Pengcheng Zhong et al.
Experimental and therapeutic medicine, 21(4), 305-305 (2021-03-16)
Although keratin 15 (KRT15) has been indicated to be overexpressed in several types of tumor, its role in breast invasive carcinoma (BRCA) has so far remained elusive. The aim of the present study was to explore KRT15 expression in BRCA
Gerald R Cunha et al.
Differentiation; research in biological diversity, 103, 24-45 (2018-09-19)
This paper provides a detailed compilation of human prostatic development that includes human fetal prostatic gross anatomy, histology, and ontogeny of selected epithelial and mesenchymal differentiation markers and signaling molecules throughout the stages of human prostatic development: (a) pre-bud urogenital
Gerald R Cunha et al.
Differentiation; research in biological diversity, 115, 37-52 (2020-08-30)
The goal of this paper is to explore the ability of the human female urogenital sinus immediately below the bladder (proximal urethra) to undergo prostatic development in response to dihydrotestosterone (DHT). To establish this idea, xenografts of human fetal female

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