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SAB4501477

Sigma-Aldrich

Anti-5-HT-2C antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 2C, Serotonin receptor 2C

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 51 kDa

reatividade de espécies

human, rat, mouse

concentração

~1 mg/mL

técnica(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

nº de adesão NCBI

P28335

nº de adesão UniProt

P28335

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... HTR2C(3358)

Categorias relacionadas

Descrição geral

5-HT-2C/HTR2C (5-hydroxytryptamine receptor 2C) receptor is a seven transmembrane domain protein. It is located on human chromosome Xq22-23.
Anti-5-HT-2C antibody detects endogenous levels of total 5-HT-2C protein.

Imunogênio

The antiserum was produced against synthesized peptide derived from human 5-HT-2C.

Immunogen Range: 161-210

Ações bioquímicas/fisiológicas

In the nervous system, 5-HT-2C/HTR2C (5-hydroxytryptamine receptor 2C) participates in coordinating the intracellular responses to serotonin. It plays a major role in the modulation of energy homeostasis.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
Xu Y, et al.
Neuron, 60(4), 582-589 (2008)
Gene structure and expression of serotonin receptor HTR2C in hypothalamic samples from infanticidal and control sows
Quilter CR, et al.
BMC Neuroscience (2012)
Rajat K Das et al.
Respiratory physiology & neurobiology, 260, 105-113 (2018-11-18)
Hypoglossal (XII) motoneurons are activated by type 2 receptors for serotonin (5-HT). This activation is especially strong during wakefulness which facilitates diverse motor functions of the tongue, including the maintenance of upper airway patency in obstructive sleep apnea (OSA) patients.
Katsura Nozawa et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3408-3413 (2009-02-13)
Serotonin (5-hydroxytryptamine; 5-HT) is abundantly present throughout the gastrointestinal tract and stored mostly in enterochromaffin (EC) cells, which are located on the mucosal surface. 5-HT released from EC cells stimulate both intrinsic and extrinsic nerves, which results in various physiological
Nadja Osterberg et al.
Cell and tissue research, 336(1), 11-20 (2009-02-19)
Serotonergic (5-HT) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. However, the molecular mechanisms underlying the differentiation of

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