SAB4300644

Anti-TAZ antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Anti-WWTR1
• Código UNSPSC: 12352203
• NACRES: NA.41
• conjugado: unconjugated
• application: WB
• clone: polyclonal
• reatividade de espécies: rat, human, mouse
• técnica(s): western blot: 1:500-1:1000

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: ~49 kDa
• reatividade de espécies: rat, human, mouse
• concentração: 1 mg/mL
• técnica(s): western blot: 1:500-1:1000
• Isotipo: IgG
• sequência de imunogênio: (V-E-S-A-L)
• nº de adesão NCBI: NM_001168278.1
• nº de adesão UniProt: Q16635
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... TAZ(25937)

Descrição

Descrição geral

The antibody detects endogenous level of total TAZ protein.

Imunogênio

Peptide sequence around aa. 386-390 (V-E-S-A-L), according to the protein NP_001161750.1

Características e benefícios

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Descrição-alvo

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable