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SAB4200823

Sigma-Aldrich

Anti- Protease-7 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Omptin, Outer membrane protein 3B, Protease A, Protease VII

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

descrição

Research area: Microbiome

forma

buffered aqueous solution

reatividade de espécies

E. coli, Shigella flexneri

embalagem

antibody small pack of 25 μL

concentração

~1.0 mg/mL

técnica(s)

immunoblotting: 0.5-1 μg/mL using E. coli lysate.

nº de adesão UniProt

P09169

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

Escherichia coli K12 ... ompT(945185)
Shigella flexneri ... ompT(1238162)

Categorias relacionadas

Descrição geral

E. coli Protease-7, also known as Omptin (ompT) or Outer membrane protein 3B, belongs to the omptin family of outer membrane proteases found in several Gram-negative bacteria of the Enterobacteriaceae family. Omptins are unique proteases combining features of both serine and aspartate proteases activity. Several group members may also have cysteine protease and metalloproteases activities, all share a conserved active site. The enzyme proteolytic activity is dependent on the interaction with the lipid A region of the lipopolysaccharide (LPS).

Imunogênio

Synthetic peptide corresponding to human N-terminal region E.coli Protease7, conjugated to KLH

Aplicação

Anti-Protease-7 antibody specifically recognizes Protease-7 from E. coli and Shigella flexneri and does not cross react with Proteus mirabilis. The antibody may be used in various immunochemical techniques including Immunoblotting (doublet ~35 kDa).

forma física

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Exoneração de responsabilidade

This product is for R&D use only, not for drug, household, or other uses.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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L Vandeputte-Rutten et al.
The EMBO journal, 20(18), 5033-5039 (2001-09-22)
OmpT from Escherichia coli belongs to a family of highly homologous outer membrane proteases, known as omptins, which are implicated in the virulence of several pathogenic Gram-negative bacteria. Here we present the crystal structure of OmpT, which shows a 10-stranded
Akiko Urashima et al.
Cellular microbiology, 19(11) (2017-06-18)
Antimicrobial peptides (AMPs) are important components of the innate immune system. Enterohaemorrhagic Escherichia coli (EHEC), a food-borne pathogen causing serious diarrheal diseases, must overcome attack by AMPs. Here, we show that resistance of EHEC against human cathelicidin LL-37, a primary
Jenny-Lee Thomassin et al.
Infection and immunity, 80(2), 483-492 (2011-12-07)
Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) are food-borne pathogens that cause serious diarrheal diseases. To colonize the human intestine, these pathogens must overcome innate immune defenses such as antimicrobial peptides (AMPs). Bacterial pathogens have evolved various mechanisms
John R Brannon et al.
Infection and immunity, 83(6), 2300-2311 (2015-04-01)
Bacterial proteases are important virulence factors that inactivate host defense proteins and contribute to tissue destruction and bacterial dissemination. Outer membrane proteases of the omptin family, exemplified by Escherichia coli OmpT, are found in some Gram-negative bacteria. Omptins cleave a

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