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SAB4300602

Sigma-Aldrich

Anti-EGFR (Ab-1197) antibody produced in goat

affinity isolated antibody

Sinônimo(s):

Anti-ERBB antibody produced in goat, Anti-ERBB1 antibody produced in goat, Anti-HER1 antibody produced in goat, Anti-PIG61 antibody produced in goat, Anti-epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) antibody produced in goat

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

goat

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

peso molecular

~175 kDa

reatividade de espécies

rat, mouse, human

concentração

1 mg/mL

técnica(s)

western blot: 1:500-1:1000

Isotipo

IgG

sequência de imunogênio

(A-E-Y-L-R)

nº de adesão NCBI

NP_005219.2

nº de adesão UniProt

P00533

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... EGFR(1956)

Categorias relacionadas

Descrição geral

Epidermal growth factor receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including transforming growth factor-α (TGF-α), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), amphiregulin, epiregulin and epigen. The gene encoding it is localized on human chromosome 7p11.2.

Imunogênio

Peptide sequence around aa. 1195-1199 (A-E-Y-L-R), according to the protein EGFR.

Ações bioquímicas/fisiológicas

Upon activation by ligands, epidermal growth factor receptor (EGFR, ErbB1) initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrição-alvo

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Preços

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
951421551

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Journal of pharmacological sciences, 126(1), 77-83 (2014-09-23)
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Applied immunohistochemistry & molecular morphology : AIMM, 22(9), 674-680 (2014-10-04)
Although enhanced epidermal growth factor receptor (EGFR) signaling has been connected with glottic cancerogenesis, the precise mechanisms of its activation still remain unclear. The aim of the present study was to examine EGFR on protein level, confronting cellular pattern of
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Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab.
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