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SAB4300397

Sigma-Aldrich

Anti-MYOD1 (Ab-200) antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Anti-MYF3 antibody produced in rabbit, Anti-MYOD antibody produced in rabbit, Anti-PUM antibody produced in rabbit, Anti-bHLHc1 antibody produced in rabbit, Anti-myogenic differentiation 1 antibody produced in rabbit

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About This Item

Número MDL:
MFCD01323984
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

peso molecular

~40 kDa

reatividade de espécies

mouse, human, rat

concentração

1 mg/mL

técnica(s)

western blot: 1:500-1:1000

Isotipo

IgG

sequência de imunogênio

(A-S-S-P-R)

nº de adesão NCBI

NP_002469.2

nº de adesão UniProt

P15172

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... MYOD1(4654)

Descrição geral

MYOD1 (myogenic differentiation 1) gene codes for a nuclear protein, that is a member of the basic helix-loop-helix (bHLH) family of transcription factors and the myogenic factors subfamily. It is located on human chromosome 11p15.1.

Imunogênio

Peptide sequence around aa. 198!202 (A-S-S-P-R), according to the protein MYOD1.

Ações bioquímicas/fisiológicas

Lack of MyoD (myogenic differentiation) results in a perinatally lethal fetal akinesia. It brings histone-modifying enzymes, which help to induce muscle differentiation.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrição-alvo

MyoD encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Preços

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
871521124

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A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations
Kohsaka S, et al.
Nature Genetics, 46(6), 595-600 (2014)
Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal akinesia
Watson CM, et al.
Journal of medical Genetics, 53(4), 264-269 (2016)
Manuela Dos Santos et al.
Advances in rheumatology (London, England), 62(1), 27-27 (2022-07-23)
Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE). Because of the poor understanding of signaling pathways involved in SLE muscle wasting, the  aim of this study was to evaluate the effects of vitamin D supplementation
Narasimhan P Agaram et al.
Genes, chromosomes & cancer, 53(9), 779-787 (2014-05-16)
Sclerosing and spindle cell rhabdomyosarcoma (RMS) are rare types of RMS recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS (ERMS). Although sclerosing and spindle cell RMS share clinical and morphologic features, a pathogenetic link based on shared
J Spring
FEBS letters, 400(1), 2-8 (1997-01-02)
For the growing fraction of human genes with identified functions there are often homologues known from invertebrates such as Drosophila. A survey of well established gene families from aldolases to zinc finger transcription factors reveals that usually a single invertebrate
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