MABS26

Anti-LDLR Antibody, clone C7

clone C7, from mouse

• Sinônimo(s): low density lipoprotein receptor, LDL receptor
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• forma do anticorpo: purified antibody
• tipo de produto de anticorpo: primary antibodies
• clone: C7, monoclonal
• reatividade de espécies: human
• reatividade da espécie (prevista por homologia): bovine (based on 100% sequence homology)
• técnica(s): western blot: suitable
• Isotipo: IgG2bκ
• nº de adesão NCBI: NP_001160002
• nº de adesão UniProt: P01131
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... LDLR(3949)

Descrição

Descrição geral

Low-Density Lipoprotein (LDL) Receptor is a mosaic protein that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). Mutations in LDLR are associated with familial hypercholesterolemia which is characterized by high levels of LDL in the blood.

Especificidade

This antibody recognizes LDLR.

Imunogênio

Partially purified bovine adrenal LDL receptor

Aplicação

Research Category
Metabolism

Research Sub Category
Lipid Metabolism & Weight Regulation

This Anti-LDLR Antibody, clone C7 is validated for use in WB for the detection of LDLR.

Qualidade

Evaluated by Western Blot in ARPE-19 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected LDLR on 10 µg of ARPE-19 cell lysate.

Descrição-alvo

160 kDa Observed The translation of LDLR mRNA yields a 120 kDa protein that is post-translationally modified in the Golgi apparatus into the mature, 160 kDa LDLR. (Tolleshaug, H., et al. (1982). Cell 30:715–724.)

forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
ARPE-19 cell lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable