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SAB4300100

Sigma-Aldrich

Anti-phospho-ATM (pSer1981) antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Anti-AT1 antibody produced in rabbit, Anti-ATA antibody produced in rabbit, Anti-ATC antibody produced in rabbit, Anti-ATD antibody produced in rabbit, Anti-ataxia telangiectasia mutated antibody produced in rabbit

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About This Item

Número MDL:
MFCD01321727
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

peso molecular

~350 kDa

reatividade de espécies

human

concentração

1 mg/mL

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

Isotipo

IgG

sequência de imunogênio

(E-G-SP-Q-S)

nº de adesão NCBI

NP_000042.3

nº de adesão UniProt

Q13315

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

phosphorylation (pSer1981)

Informações sobre genes

human ... ATM(472)

Imunogênio

Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S), according to the protein ATM.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrição-alvo

ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cyclecheckpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins,including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNArepair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cellcycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcriptvariants encoding different isoforms have been found for this gene.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
871511122

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Protein kinase C (PKC)-interacting cousin of thioredoxin (PICOT; also termed glutaredoxin 3 (Glrx3)) is a ubiquitously expressed protein that possesses an N-terminal monothiol thioredoxin (Trx) domain and two C-terminal tandem copies of a monothiol Glrx domain. It has an overall
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