SAB4300069

Anti-phospho-IGF1R (pTyr¹¹⁶⁵/pTyr¹¹⁶⁶) antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Anti-CD221 antibody produced in rabbit, Anti-IGFIR antibody produced in rabbit, Anti-JTK13 antibody produced in rabbit, Anti-MGC142170 antibody produced in rabbit, Anti-insulin-like growth factor 1 receptor antibody produced in rabbit
• Número MDL: MFCD00282340
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: ~200 kDa; ~95 kDa
• reatividade de espécies: rat, mouse, human
• concentração: 1 mg/mL
• técnica(s): indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotipo: IgG
• sequência de imunogênio: (T-D-YP-YP-R-K)
• nº de adesão NCBI: NP_000866.1
• nº de adesão UniProt: P08069
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pTyr1165/pTyr1166)
• Informações sobre genes: human ... IGF1R(3480)

Descrição

Descrição geral

Insulin like growth factor 1 receptor (IGF1R) is encoded by the gene mapped to human chromosome 15q25- qter. The encoded protein is a transmembrane heterotetramer. It is structurally similar to insulin receptor.

Imunogênio

Peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y(p)-Y(p)-R-K), according to the protein IGF1R.

Ações bioquímicas/fisiológicas

Insulin like growth factor 1 receptor (IGF1R) on binding to its ligand, IGF2 regulates cell proliferation and growth. The encoded protein is also facilitates the normal embryonic and postnatal growth. It plays a crucial role in the embryonic growth. Mutations in IGF2 are associated with Silver–Russell syndrome and ring chromosome 15 syndrome. It is upregulated in ovarian cancer.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrição-alvo

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable