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Documentos Principais

SAB4300001

Sigma-Aldrich

Anti-phospho-GSK3B (pSer9) antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Anti-glycogen synthase kinase 3 beta antibody produced in rabbit

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About This Item

Número MDL:
MFCD03455746
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

peso molecular

~46 kDa

reatividade de espécies

mouse, rat, human

concentração

1 mg/mL

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

Isotipo

IgG

sequência de imunogênio

(T-T-SP-F-A)

nº de adesão NCBI

NP_001139628.1

nº de adesão UniProt

P49841

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

phosphorylation (pSer9)

Informações sobre genes

human ... GSK3B(2932)

Imunogênio

Peptide sequence around phosphorylation site of serine 9 (T-T-S(p)-F-A), according to the protein GSK3B.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrição-alvo

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
511711002

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Shayesteh Mehdinejadiani et al.
Biology of reproduction, 100(3), 641-648 (2018-09-06)
Polycystic ovary syndrome (PCOS) is an endocrine disorder in women of reproductive age. In addition to anovulation, endometrial dysfunction can reduce fertility in PCOS. The cyclical changes of endometrium are controlled by estrogen and progesterone via modulating the Wnt/B-catenin pathway.
Xiujing Feng et al.
Journal of cellular physiology, 234(10), 18994-19009 (2019-03-29)
Acute kidney injury (AKI) is a frequent and serious complication of sepsis; however, there are currently no effective therapies. Inflammation and oxidative stress are the major mechanisms implicated in lipopolysaccharide (LPS)-induced AKI. Dexmedetomidine (DEX) has been reported to have remarkable
Yea-Hwey Wang et al.
Food & function, 10(8), 4725-4738 (2019-07-16)
Antrodia camphorata is a well-known traditional Chinese mushroom used as a functional food and nutraceutical in Taiwan and China. The aim of this study was to explore the protective effects and mechanism(s) of the ethyl acetate crude extract of A.
Tina M Thornton et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 43(2), 393-405 (2017-08-24)
GSK3β plays an essential role in promoting cell death and is emerging as a potential target for neurological diseases. Understanding the mechanisms that control neuronal GSK3β is critical. A ubiquitous mechanism to repress GSK3β involves Akt-mediated phosphorylation of Ser
Dongmei Su et al.
Histochemistry and cell biology, 152(3), 217-225 (2019-06-15)
Gestational diabetes mellitus is a risk factor for congenital heart defects. Our previous results indicated that a decrease in myocardial cells and an increase in apoptotic cells leads to heart defects under hyperglycemia, but much work remains to elucidate this
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