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SAB4200755

Sigma-Aldrich

Anti-Human IgE-Peroxidase antibody, Mouse monoclonal

clone GE-1, purified from hybridoma cell culture

Sinônimo(s):

Anti-Immunoglubulin E

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.46

fonte biológica

mouse

Nível de qualidade

200

conjugado

peroxidase conjugate

forma do anticorpo

purified from hybridoma cell culture

tipo de produto de anticorpo

primary antibodies

clone

GE-1, monoclonal

Formulário

lyophilized powder

reatividade de espécies

human

técnica(s)

ELISA: 1:20,000-1:30,000 using 5 μg/mL Human IgE myeloma for coating

Isotipo

IgG2b

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Descrição geral

Monoclonal Anti-Human IgE (mouse IgG2b isotype) is derived from the GE-1 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgE myeloma protein. IgE (Immunoglobulin E) is the least abundant immunoglobulin isotype. IgE is produced by plasma cells and is highly functional in the lung, skin, and mucous membranes. Normal levels of IgE in serum are less than 1 μmL.

Especificidade

Monoclonal Anti-Human IgE specifically recognizes Human IgE. The antibody shows no cross-reactivity with human IgG1, IgG2, IgG3, IgG4, IgA, and IgM.

Imunogênio

Purified human IgE

Aplicação

Anti-Human IgE-Peroxidase antibody has been used in enzyme linked immunosorbent assay (ELISA).

Ações bioquímicas/fisiológicas

IgE plays a critical role in allergic reactions and host protection from parasites. During an allergic reaction such as atopic eczema, extrinsic asthma or hay fever, fungal and parasitic infection, atopic disease, or primary immunodeficiency the serum IgE levels can be induced up to 5-fold. IgE specifically and reversibly binds to the membrane receptor Fc-epsilon receptors (FcεR) type I on the surface of basophils, eosinophils, and mast cells. This binding activates the release of histamine, leukotrienes, and other mediators responsible for hypersensitivity. The recognition and isolation of allergen-specific IgE can lead to progress in understanding of pathophysiologic mechanisms underlying IgE-associated allergic disorders.

forma física

Supplied as a lyophilized powder.

Outras notas

This product is for R&D use only, not for drug, household, or other uses.

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Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H317

Classificações de perigo

Skin Sens. 1

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
047M4811V
51170404

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IgE and mast cells in allergic disease
Galli S J and Tsai M
Nature Medicine, 18(5), 693-693 (2012)
IgE and mast cells in allergic disease
Wachholz P A, et al.
Journal of Immunotoxicology, 1(3-4), 189-199 (2005)
R H Buckley et al.
The Journal of clinical investigation, 55(1), 157-165 (1975-01-01)
Concentrations of IgD and IgE were measured in sera from 165 patients with well-defined immunodeficiency in an effort to find information possibly relevant to the roles of antibodies of these classes in host defense. Values for both immunoglobulins were generally
F Zellweger et al.
Allergy, 71(12), 1652-1661 (2016-10-07)
IgE-associated allergic diseases belong to the most common inflammatory conditions. Their clinical manifestation ranges from mild symptoms to life-threatening episodes. Often patients experience a reduction in physical and psychologic well-being and suffer from a decreased quality of life due to
T J Suutari et al.
Journal of investigational allergology & clinical immunology, 16(5), 296-302 (2006-10-17)
Allergic reactions to cow's milk are common in small children. One of the main protein allergens found in cow's milk is beta-lactoglobulin (beta-Lg). Reindeer and bovine milk both contain related beta-Lg proteins, but the allergenicity of reindeer beta-Lg has not
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Global Trade Item Number

SKUGTIN
SAB4200755-1VL4061823904537

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