SAB4200078

Anti-Coronin-1A (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• Sinônimo(s): Anti-CLABP, Anti-CLIPINA (coronin-like protein A), Anti-CORO1A, Anti-HCORO1, Anti-TACO (tryptophane aspartate-containing coat protein), Anti-p57
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen ~57 kDa
• reatividade de espécies: mouse, human, rat
• concentração: ~1.5 mg/mL
• técnica(s): western blot: 1.5-3.0 μg/mL using Jurkat cell lysates, or lysates of mouse brain (S1 fraction) or rat spleen (S1 fraction)
• nº de adesão UniProt: P31146
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... CORO1A(11151) ; mouse ... Coro1a(12721) ; rat ... Coro1a(155151)

Descrição

Descrição geral

Coronin 1A (Coronin-1A) is encoded by the gene mapped to human chromosome 16p11.2. The encoded 57kDa protein, belongs to the coronin family and is mainly expressed in hematopoietic cells. Coronin family of proteins are characterized with a highly conserved N-terminal extension (NE), five canonical WD40 repeats, a C-terminal conserved extension (CE), followed by a unique region (U), and ends with a C-terminal coiled-coil (CC) domain.

Aplicação

Anti-Coronin-1A (N-terminal) antibody produced in rabbit has been used in immunoblotting.

Ações bioquímicas/fisiológicas

Coronin 1A (Coronin-1A) plays a vital role in F-actin stabilization in vitro. It is also involved in phagocytosis by neutrophils and macrophages and in T-cell receptor (TCR)-mediated activation of T lymphocytes. Additionally, it is also implicated in the regulation of activate actin-related protein-2/3 (Arp2/3)-dependent processes. Mutation in the gene has been observed in T cell-deficient, B cell- and natural killer (NK) cell-sufficient (T?B⁺NK⁺) severe combined immunodeficiency (SCID) patients.

Coronin-1A also plays a vital role in regulation of leukocyte specific signaling. In T-lymphocytes, coronin-1A facilitates the association of cytoskeleton dynamics to TCRαβ induced cell signaling, chemokine-mediated cell migration and homeostasis. Loss of coronin-1A gene expression in murine T cells leads to reduced ability to respond to chemotactic gradient and decrease in peripheral T cells due to apoptosis.

forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable