SAB3600001
Anti-IGF-1 antibody produced in goat
affinity isolated antibody, lyophilized powder
Sinônimo(s):
Anti-Insulin-like Growth Factor-I
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About This Item
Produtos recomendados
fonte biológica
goat
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
forma
lyophilized powder
reatividade de espécies
human
técnica(s)
immunocytochemistry: 5-15 μg/mL
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: 0.1-0.2 μg/mL
aplicação(ões)
research pathology
temperatura de armazenamento
−20°C
Informações sobre genes
human ... IGF1(3479)
Descrição geral
Insulin-like growth factor-I (IGF-I) is encoded by the gene mapped to human chromosome 12q23.2. IGF-I belongs to insulin-like growth factor (IGF) family. The encoded protein is ubiquitously expressed, but the circulating form of the protein is mainly found in liver and pancreas.
Imunogênio
purified, E. coli-derived recombinant human insulin-like growth factor-I.
Aplicação
Anti- IGF-1 antibody may be used for neutralization reactions, the ND50 of the antibody is 3-12 μg/ml. For immunoblotting a working antibody concentration of 0.1-0.2 μg/ml. The recommended antibody concentration for immunocytochemistry is 5-15 μg/ml. The antibody is suitable for immunohistochemistry of formalin-fixed, paraffin-embedded sections.
Ações bioquímicas/fisiológicas
Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1 signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate. Anti-IGF-I recognizes human insulin-like growth factor I.
forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
13 - Non Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients.
Squassina A, et al.
Pharmacological Research, 73, 1-7 (2013)
Insulin-like growth factor system and sporadic malignant melanoma.
Capoluongo E et al
The American Journal of Pathology, 178, 26-31 (2011)
H Yu et al.
Journal of the National Cancer Institute, 91(2), 151-156 (1999-01-29)
Insulin-like growth factors (IGFs), in particular IGF-I and IGF-II, strongly stimulate the proliferation of a variety of cancer cells, including those from lung cancer. To examine the possible causal role of IGFs in lung cancer development, we compared plasma levels
J M Chan et al.
Science (New York, N.Y.), 279(5350), 563-566 (1998-02-07)
Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases
S E Hankinson et al.
Lancet (London, England), 351(9113), 1393-1396 (1998-05-21)
Insulin-like growth factor (IGF)-I, a mitogenic and antiapoptotic peptide, can affect the proliferation of breast epithelial cells, and is thought to have a role in breast cancer. We hypothesised that high circulating IGF-I concentrations would be associated with an increased
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